VEGFR-TKIs alone or in combination with immune checkpoint inhibitors in clinical practice for the treatment of HCC

December 02, 2021 00:29:56
VEGFR-TKIs alone or in combination with immune checkpoint inhibitors in clinical practice for the treatment of HCC
COR2ED Medical Education
VEGFR-TKIs alone or in combination with immune checkpoint inhibitors in clinical practice for the treatment of HCC

Dec 02 2021 | 00:29:56

/

Show Notes

In this medical education podcast episode, Prof. Peter Galle and Prof. Amit Singal discuss the use of VEGFR-TKIs in the treatment of advanced or unresectable HCC and explain the immunomodulation rationale to combine it with immune checkpoint inhibitor.

Combination approach has been validated recently with the atezolizumab+bevacizumab combination being the new standard of care in 1L setting for advanced HCC patients. In the context of advanced HCC, both experts share their view about the dosing approach with VEGFR-TKI and provide insight to handle the dosing when combining with PD-1 inhibitor.

Both experts reiterate that biomarkers are urgently needed in HCC and summarize the current stratification of patients used to predict the response with VEGFR-TKI monotherapy or in immunotherapy combination. Finally, they emphasize that pre-habilitation of HCC patients is key to make the HCC patient fit for the best available treatment option.

Other Episodes

Episode 1

May 03, 2022 00:22:30
Episode Cover

Immune tolerance induction in the era of emicizumab

COR2ED Medical Education: In this podcast, two haematology experts discuss their views on the use of immune tolerance induction (ITI) in haemophilia. Prof. Jan...

Listen

Episode 0

January 28, 2022 00:31:03
Episode Cover

Genetic testing and PARP inhibitors in prostate cancer

COR2ED Medical Education: Joanne Chien, Nurse Practitioner specialising in urologic cancers at Stanford Health Care in Palo Alto, California, and Dr Alexander Wyatt, Assistant...

Listen

Episode

November 29, 2023 00:27:39
Episode Cover

Gene therapy and gene-modified cell therapy in rare diseases

Gene therapy and gene-modified cell therapies have a great potential for rare diseases to either help patients to cure their disease or improve their...

Listen