ASBMR 2022 Rare Bone Disease Highlights: Episode 2

Episode 2 September 14, 2022 00:15:17
ASBMR 2022 Rare Bone Disease Highlights: Episode 2
COR2ED Medical Education
ASBMR 2022 Rare Bone Disease Highlights: Episode 2

Sep 14 2022 | 00:15:17

/

Show Notes

In this second episode of a three-episode podcast series, COR2ED and ASBMR have partnered with Professor Eric Rush (Children’s Mercy Hospital) to provide rare bone disease highlights from ASBMR 2022 Annual Meeting.

Prof. Rush opens with detailed information on fibrodysplasia ossificans progressiva (FOP): symptoms of this severe congenital condition include permanent heterotopic ossifications preceded by painful soft tissue swelling. Nearly all patients have the same ACVR1 receptor variant, and Prof. Rush shares therapy options for the disease. He then offers insights on hypochondroplasia (HCH), a developmental disorder caused by a defect in the FGFR3 gene. An animal model for HCH has been developed, in which infigratinib, a selective FGFR tyrosine kinase inhibitor, shows positive effects on growth as well as proportion. He then describes a clinical study in osteogenesis imperfects (OI), in which allogenic transplantation of fetal liver-derived mesenchymal stem cells was tested in children with type III and type IV OI. While increased bone density and height were observed, Prof. Rush cautions that both the number of study participants and the study duration were low. He closes the podcast with personal insights from the in-person Annual Meeting, including opportunities for engagement and exchange at “Meet the Professor” sessions.

Other Episodes

Episode

December 04, 2023 00:33:58
Episode Cover

Diagnosis and management of short stature patients

Do you know how to differentiate between growth hormone deficiency (or GHD) and primary IGF-I deficiency (or growth hormone resistance) and the key challenges...

Listen

Episode 1

September 08, 2021 00:12:56
Episode Cover

Nurse management of AEs in patients receiving VEGFR-TKIs

In this podcast, Veerle Lamotte, an oncology nurse practitioner at Antwerp University Hospital and Paola Belardi, nurse chief at San Donato Hospital in Arezzo,...

Listen

Episode 1

November 25, 2022 00:22:02
Episode Cover

Why iron matters in women with bleeding disorders

COR2ED Medical Education: In this podcast, Haematologists Dr Michelle Lavin and Dr Roseline d’Oiron discuss the importance of recognising and correcting iron deficiency in...

Listen